The mitogen-stimulated protein kinase p70 ribosomal protein S6 kinase 1 (S6K1) is a member of a family of serine/threonine protein kinases that phosphorylate the 40S ribosomal protein S6, thereby modulating the translation of ribosomal proteins and translation elongation factors. p70-S6K is activated in response to the phosphatidylinositol 3-kinase (PI3K) and mitogenactivated protein kinase (MAPK) pathways, and is required for progression through the cell cycle and for cell growth. Activation of p70-S6K is regulated by phosphorylation of seven different residues distributed throughout the protein. Symansis 3009-1C is a polyclonal sheep antibody raised to the C-terminus of human p70S6K protein. The antibody works excellently in western blots and is expected to work well in native applications as well but it is, as yet, untested in those applications. |
新西兰Symansis公司是新西兰一家发展抗体作为新药开发中细胞讯息传递研究工具的公司。
Symansis公司新推出Multi-Kinase ELISA Arrays试剂盒,采用特异的抗磷酸化激酶抗体和ELISA反应原理,使磷酸化激酶的检测变得简单。一次操作,可同时检测多个磷酸化激酶,避免了传统的Western blot方法需要分开操作及其一系列复杂繁琐的操作和等待。其酶抑制剂产品如下:
AKT AKt-I-1 SY AKT-I-1
AMPK A-769662 SY-A-769662
AUR (CDK) JNJ7706621 SY- JNJ7706621
Aurora VX-680 SY- VX-680
Bcl-2 ABT-737 SY- ABT-737
BCR-ABL Imatinib mesylate SY- Imatinib mesylate
BCR-ABL PD173955 SY-PD173955
CDK AT-7519 SY- AT-7519
CDK SNS-032 SY- SNS-032
EGFR Gefitinib SY- Gefitinib
EGFR Erlotinib SY- Erlotinib