CD33 - Fc Chimera/Siglec-3 - Fc Chimera
Symansis" Siglec-3 - Fchcx Chimera has N-linked oligosaccharides, shown by a drop in observed MW on SDS-PAGE after treatment with PNGase F. Symansis" Siglec-3 - Fchcx Chimera contains 10-30% carbohydrate by weight. Densitometry of protein isoforms visualized by 2-DE. Spot trains are normal in human proteins and highlight the presence of multiple isoforms which differ according to their level of post-translational modification. The triangle indicates the theoretical MW and pI of the protein. 1D SDS-PAGE of Symansis" hcx protein before and after treatment with glycosidases to remove oligosaccharides. A drop in the observed MW after treatment indicates the presence of glycosylation. 1. Varki et al. (2006) Glycobiology 16:1R-27R | |  |
新西兰Symansis公司是新西兰一家发展抗体作为新药开发中细胞讯息传递研究工具的公司。
Symansis公司新推出Multi-Kinase ELISA Arrays试剂盒，采用特异的抗磷酸化激酶抗体和ELISA反应原理，使磷酸化激酶的检测变得简单。一次操作，可同时检测多个磷酸化激酶，避免了传统的Western blot方法需要分开操作及其一系列复杂繁琐的操作和等待。其酶抑制剂产品如下：
AKT AKt-I-1 SY AKT-I-1
AMPK A-769662 SY-A-769662
AUR (CDK) JNJ7706621 SY- JNJ7706621
Aurora VX-680 SY- VX-680
Bcl-2 ABT-737 SY- ABT-737
BCR-ABL Imatinib mesylate SY- Imatinib mesylate
BCR-ABL PD173955 SY-PD173955
CDK AT-7519 SY- AT-7519
CDK SNS-032 SY- SNS-032
EGFR Gefitinib SY- Gefitinib
EGFR Erlotinib SY- Erlotinib
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