The C1q TNF-related proteins (CTRPs) are a newly discovered highly conserved family of adiponectin paralogs, containing 15 members (CTRP1 to CTRP15). Although structurally related, the CTRP family members are functionally diverse. C1q-TNF-related protein-9 (CTRP9) is increasingly recognized as a promising cardioprotective adipocytokine, which regulates biological processes like vascular relaxation, proliferation, apoptosis, and inflammation. CTRP9 is the closest adiponectin paralog, and is predominantly expressed in adipose tissue. It also forms heterotrimers with adiponectin, and similarly to mouse adiponectin, reduces serum glucose. While many of CTRP9’s metabolic roles overlap those of adiponectin, CTRP9 is also being studied for its beneficial cardiovascular effects, especially related to atherosclerosis. For instance, in aortic vascular rings, CTRP9 caused significant vasorelaxation, and the vasoactive potency of CTRP9 exceeded that of adiponectin by 3-fold. This effect was endothelium-dependent and nitric oxide-mediated. Furthermore, CTRP9 modulates neointimal hyperplasia and vascular smooth muscle cell proliferation in vivo and in vitro. Moreover, a recent study found that CTRP9 attenuated adverse cardiac remodeling after ischemia-perfusion injury in mice. Thus, CTRP9 is likely to be involved in the regulation of vascular function, more specifically atherosclerosis, in both rodents and humans (Jung CH et al.,J Clin Endocrinol Metab. 2014 Dec;99(12):E2477-84).
新西兰Symansis公司是新西兰一家发展抗体作为新药开发中细胞讯息传递研究工具的公司。
Symansis公司新推出Multi-Kinase ELISA Arrays试剂盒,采用特异的抗磷酸化激酶抗体和ELISA反应原理,使磷酸化激酶的检测变得简单。一次操作,可同时检测多个磷酸化激酶,避免了传统的Western blot方法需要分开操作及其一系列复杂繁琐的操作和等待。其酶抑制剂产品如下:
AKT AKt-I-1 SY AKT-I-1
AMPK A-769662 SY-A-769662
AUR (CDK) JNJ7706621 SY- JNJ7706621
Aurora VX-680 SY- VX-680
Bcl-2 ABT-737 SY- ABT-737
BCR-ABL Imatinib mesylate SY- Imatinib mesylate
BCR-ABL PD173955 SY-PD173955
CDK AT-7519 SY- AT-7519
CDK SNS-032 SY- SNS-032
EGFR Gefitinib SY- Gefitinib
EGFR Erlotinib SY- Erlotinib